1ROS

Crystal structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Macrophage metalloelastase	polymer	163	18101.2	2	UniProt (P39900) Pfam (PF00413) In PDB	Homo sapiens (human)	HME, Matrix metalloproteinase-12, MMP-12, Macrophage elastase, ME
2	A, B	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
3	A, B	CALCIUM ION	non-polymer		40.1	6	Chemie (CA)
4	A, B	2-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL]-4-(4'-ETHOXY-1,1'-BIPHENYL-4-YL)-4-OXOBUTANOIC ACID	non-polymer		471.5	2	Chemie (DEO)
5		water	water		18.0	276	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	36202.3
Non-Polymers*	Number of molecules	12
	Total formula weight	1445.1
All*	Total formula weight	37647.4

*Water molecules are not included.