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1ROS

Crystal structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0031012cellular_componentextracellular matrix
B0004222molecular_functionmetalloendopeptidase activity
B0006508biological_processproteolysis
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0031012cellular_componentextracellular matrix
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 400
ChainResidue
ADEO1
AHIS218
AHIS222
AHIS228

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 401
ChainResidue
AHIS168
AASP170
AHIS183
AHIS196

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 402
ChainResidue
AGLY176
AGLY178
AILE180
AASP198
AGLU201
AASP175

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 403
ChainResidue
AASP158
AGLY190
AGLY192
AASP194

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 404
ChainResidue
AASP124
AGLU199
AGLU201
AHOH497

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 500
ChainResidue
BDEO1
BHIS218
BHIS222
BHIS228

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 501
ChainResidue
BHIS168
BASP170
BHIS183
BHIS196

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 502
ChainResidue
BASP175
BGLY176
BGLY178
BILE180
BASP198
BGLU201

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 503
ChainResidue
BASP158
BGLY190
BGLY192
BASP194
BHOH591

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA B 504
ChainResidue
BASP124
BGLU199
BGLU201
BHOH565

site_idBC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE DEO A 1
ChainResidue
ALEU181
AALA182
AHIS183
AALA184
AHIS218
AGLU219
AHIS222
AHIS228
AVAL235
APHE237
APRO238
ATHR239
ATYR240
ALYS241
APHE248
AZN400
AHOH427
AHOH430

site_idBC3
Number of Residues19
DetailsBINDING SITE FOR RESIDUE DEO B 1
ChainResidue
BLEU181
BALA182
BHIS183
BALA184
BHIS218
BGLU219
BHIS222
BHIS228
BVAL235
BPHE237
BPRO238
BTHR239
BTYR240
BLYS241
BPHE248
BZN500
BHOH508
BHOH513
BHOH529

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL
ChainResidueDetails
ATHR215-LEU224

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues38
DetailsBinding site: {}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
AMET236
AGLU219

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
BMET236
BGLU219

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
AGLU219

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
BGLU219

239492

PDB entries from 2025-07-30

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