1RMZ

Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor NNGH at 1.3 A resolution

Summary for 1RMZ

Entry DOI	10.2210/pdb1rmz/pdb
Related	1JK3 1OS2 1OS9
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	matrix metalloproteinase, mmp12, elastase, complex (elastase-inhibitor), metallo elastase, nngh, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P39900
Total number of polymer chains	1
Total formula weight	18183.09
Authors	Bertini, I.,Calderone, V.,Fragai, M.,Luchinat, C.,Mangani, S.,Terni, B. (deposition date: 2003-11-28, release date: 2004-12-14, Last modification date: 2023-08-23)
Primary citation	Bertini, I.,Calderone, V.,Cosenza, M.,Fragai, M.,Lee, Y.M.,Luchinat, C.,Mangani, S.,Terni, B.,Turano, P. Conformational variability of matrix metalloproteinases: beyond a single 3D structure. Proc.Natl.Acad.Sci.Usa, 102:5334-5339, 2005 Cited by PubMed: 15809432 DOI: 10.1073/pnas.0407106102 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.34 Å)

Structure validation