1UTT

Crystal Structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid

Summary for 1UTT

• Entry DOI: 10.2210/pdb1utt/pdb
• Related: 1JIZ 1JK3 1OS2 1OS9 1ROS 1UTZ
• Descriptor: MACROPHAGE METALLOELASTASE, ACETOHYDROXAMIC ACID, 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL) ETHYL-4-(4'-ETHOXY [1,1'-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID, ... (6 entities in total)
• Functional Keywords: macrophage metalloelastase, non-zinc chelator, mmp-12, mmp inhibitor, hydrolase, metalloprotease
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 18370.28

Authors

Morales, R.,Perrier, S.,Florent, J.M.,Beltra, J.,Dufour, S.,De Mendez, I.,Manceau, P.,Tertre, A.,Moreau, F.,Compere, D.,Dublanchet, A.C.,O'Gara, M. (deposition date: 2003-12-10, release date: 2004-12-15, Last modification date: 2023-12-13)

• Primary citation: Morales, R.,Perrier, S.,Florent, J.M.,Beltra, J.,Dufour, S.,De Mendez, I.,Manceau, P.,Tertre, A.,Moreau, F.,Compere, D.,Dublanchet, A.C.,O'Gara, M.; Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12.; J. Mol. Biol., 341:1063-1076, 2004; PubMed: 15289103; DOI: 10.1016/j.jmb.2004.06.039

Experimental method

X-RAY DIFFRACTION (2.2 Å)