1UTZ

Crystal Structure of MMP-12 complexed to (2R)-3-({[4-[(pyridin-4-yl)phenyl]-thien-2-yl}carboxamido)(phenyl)propanoic acid

Summary for 1UTZ

Entry DOI	10.2210/pdb1utz/pdb
Related	1JIZ 1JK3 1OS2 1OS9 1ROS 1UTT
Descriptor	MACROPHAGE METALLOELASTASE, (2R)-3-({[4-[(PYRIDIN-4-YL)PHENYL]-THIEN-2-YL}CARBOXAMIDO)(PHENYL)PROPANOIC ACID, ACETOHYDROXAMIC ACID, ... (6 entities in total)
Functional Keywords	macrophage metalloelastase, non-zinc chelator, mmp-12, mmp inhibitor, hydrolase, metalloprotease
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	37120.89
Authors	Morales, R.,Perrier, S.,Florent, J.M.,Beltra, J.,Dufour, S.,De Mendez, I.,Manceau, P.,Tertre, A.,Moreau, F.,Compere, D.,Dublanchet, A.C.,O'Gara, M. (deposition date: 2003-12-12, release date: 2004-12-15, Last modification date: 2023-12-13)
Primary citation	Morales, R.,Perrier, S.,Florent, J.M.,Beltra, J.,Dufour, S.,De Mendez, I.,Manceau, P.,Tertre, A.,Moreau, F.,Compere, D.,Dublanchet, A.C.,O'Gara, M. Crystal Structures of Novel Non-Peptidic, Non-Zinc Chelating Inhibitors Bound to Mmp-12 J.Mol.Biol., 341:1063-, 2004 Cited by PubMed: 15289103 DOI: 10.1016/J.JMB.2004.06.039 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation