Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A1268 |
Chain | Residue |
A | HIS218 |
A | HIS222 |
A | HIS228 |
A | HAE1267 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A1269 |
Chain | Residue |
A | HIS168 |
A | ASP170 |
A | HIS183 |
A | HIS196 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A1270 |
Chain | Residue |
A | GLY176 |
A | GLY178 |
A | ILE180 |
A | ASP198 |
A | GLU201 |
A | ASP175 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA A1271 |
Chain | Residue |
A | ASP124 |
A | GLU199 |
A | GLU201 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B1267 |
Chain | Residue |
B | HIS218 |
B | HIS222 |
B | HIS228 |
B | HAE1266 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B1268 |
Chain | Residue |
B | HIS168 |
B | ASP170 |
B | HIS183 |
B | HIS196 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B1269 |
Chain | Residue |
B | ASP175 |
B | GLY176 |
B | GLY178 |
B | ILE180 |
B | ASP198 |
B | GLU201 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA B1270 |
Chain | Residue |
B | ASP124 |
B | GLU199 |
B | GLU201 |
site_id | AC9 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE PF3 A1265 |
Chain | Residue |
A | GLY179 |
A | ILE180 |
A | LEU181 |
A | ALA182 |
A | HIS218 |
A | GLU219 |
A | ALA234 |
A | VAL235 |
A | PHE237 |
A | PRO238 |
A | THR239 |
A | TYR240 |
A | LYS241 |
A | PF31266 |
A | HAE1267 |
A | HOH2069 |
A | HOH2070 |
B | SER229 |
B | PRO238 |
site_id | BC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE PF3 A1266 |
Chain | Residue |
A | SER230 |
A | PHE237 |
A | PRO238 |
A | THR239 |
A | PF31265 |
B | ASP175 |
B | LYS177 |
B | GLY178 |
B | GLY179 |
B | PHE202 |
B | HIS206 |
B | GLY208 |
B | GLY209 |
B | PRO238 |
B | PF31265 |
site_id | BC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE HAE A1267 |
Chain | Residue |
A | ALA182 |
A | HIS183 |
A | HIS218 |
A | GLU219 |
A | HIS222 |
A | HIS228 |
A | PF31265 |
A | ZN1268 |
A | HOH2071 |
A | HOH2072 |
site_id | BC3 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE PF3 B1265 |
Chain | Residue |
B | HOH2059 |
A | HIS228 |
A | SER229 |
A | PF31266 |
B | GLY179 |
B | ILE180 |
B | LEU181 |
B | ALA182 |
B | LEU214 |
B | HIS218 |
B | GLU219 |
B | ALA234 |
B | VAL235 |
B | PHE237 |
B | PRO238 |
B | THR239 |
B | TYR240 |
B | LYS241 |
B | HAE1266 |
B | HOH2046 |
B | HOH2057 |
B | HOH2058 |
site_id | BC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE HAE B1266 |
Chain | Residue |
B | ALA182 |
B | HIS183 |
B | HIS218 |
B | GLU219 |
B | HIS222 |
B | HIS228 |
B | PF31265 |
B | ZN1267 |
B | HOH2059 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL |
Chain | Residue | Details |
A | THR215-LEU224 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | GLU219 | |
B | GLU219 | |
site_id | SWS_FT_FI2 |
Number of Residues | 38 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP124 | |
A | GLY190 | |
A | GLY192 | |
A | ASP194 | |
A | HIS196 | |
A | ASP198 | |
A | GLU199 | |
A | GLU201 | |
A | HIS218 | |
A | HIS222 | |
A | HIS228 | |
A | ASP158 | |
B | ASP124 | |
B | ASP158 | |
B | HIS168 | |
B | ASP170 | |
B | ASP175 | |
B | GLY176 | |
B | GLY178 | |
B | ILE180 | |
B | HIS183 | |
B | GLY190 | |
A | HIS168 | |
B | GLY192 | |
B | ASP194 | |
B | HIS196 | |
B | ASP198 | |
B | GLU199 | |
B | GLU201 | |
B | HIS218 | |
B | HIS222 | |
B | HIS228 | |
A | ASP170 | |
A | ASP175 | |
A | GLY176 | |
A | GLY178 | |
A | ILE180 | |
A | HIS183 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | MET236 | |
A | GLU219 | |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
B | MET236 | |
B | GLU219 | |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | GLU219 | |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
B | GLU219 | |