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1UTZ

Crystal Structure of MMP-12 complexed to (2R)-3-({[4-[(pyridin-4-yl)phenyl]-thien-2-yl}carboxamido)(phenyl)propanoic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0031012cellular_componentextracellular matrix
B0004222molecular_functionmetalloendopeptidase activity
B0006508biological_processproteolysis
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0031012cellular_componentextracellular matrix
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A1268
ChainResidue
AHIS218
AHIS222
AHIS228
AHAE1267

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A1269
ChainResidue
AHIS168
AASP170
AHIS183
AHIS196

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A1270
ChainResidue
AGLY176
AGLY178
AILE180
AASP198
AGLU201
AASP175

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA A1271
ChainResidue
AASP124
AGLU199
AGLU201

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B1267
ChainResidue
BHIS218
BHIS222
BHIS228
BHAE1266

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B1268
ChainResidue
BHIS168
BASP170
BHIS183
BHIS196

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B1269
ChainResidue
BASP175
BGLY176
BGLY178
BILE180
BASP198
BGLU201

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA B1270
ChainResidue
BASP124
BGLU199
BGLU201

site_idAC9
Number of Residues19
DetailsBINDING SITE FOR RESIDUE PF3 A1265
ChainResidue
AGLY179
AILE180
ALEU181
AALA182
AHIS218
AGLU219
AALA234
AVAL235
APHE237
APRO238
ATHR239
ATYR240
ALYS241
APF31266
AHAE1267
AHOH2069
AHOH2070
BSER229
BPRO238

site_idBC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE PF3 A1266
ChainResidue
ASER230
APHE237
APRO238
ATHR239
APF31265
BASP175
BLYS177
BGLY178
BGLY179
BPHE202
BHIS206
BGLY208
BGLY209
BPRO238
BPF31265

site_idBC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE HAE A1267
ChainResidue
AALA182
AHIS183
AHIS218
AGLU219
AHIS222
AHIS228
APF31265
AZN1268
AHOH2071
AHOH2072

site_idBC3
Number of Residues22
DetailsBINDING SITE FOR RESIDUE PF3 B1265
ChainResidue
BHOH2059
AHIS228
ASER229
APF31266
BGLY179
BILE180
BLEU181
BALA182
BLEU214
BHIS218
BGLU219
BALA234
BVAL235
BPHE237
BPRO238
BTHR239
BTYR240
BLYS241
BHAE1266
BHOH2046
BHOH2057
BHOH2058

site_idBC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE HAE B1266
ChainResidue
BALA182
BHIS183
BHIS218
BGLU219
BHIS222
BHIS228
BPF31265
BZN1267
BHOH2059

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL
ChainResidueDetails
ATHR215-LEU224

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE:
ChainResidueDetails
AGLU219
BGLU219

site_idSWS_FT_FI2
Number of Residues38
DetailsBINDING:
ChainResidueDetails
AASP124
AGLY190
AGLY192
AASP194
AHIS196
AASP198
AGLU199
AGLU201
AHIS218
AHIS222
AHIS228
AASP158
BASP124
BASP158
BHIS168
BASP170
BASP175
BGLY176
BGLY178
BILE180
BHIS183
BGLY190
AHIS168
BGLY192
BASP194
BHIS196
BASP198
BGLU199
BGLU201
BHIS218
BHIS222
BHIS228
AASP170
AASP175
AGLY176
AGLY178
AILE180
AHIS183

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
AMET236
AGLU219

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
BMET236
BGLU219

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
AGLU219

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
BGLU219

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PDB entries from 2024-11-13

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