1UTZ

Crystal Structure of MMP-12 complexed to (2R)-3-({[4-[(pyridin-4-yl)phenyl]-thien-2-yl}carboxamido)(phenyl)propanoic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	MACROPHAGE METALLOELASTASE	polymer	159	17631.6	2	UniProt (P39900) Pfam (PF00413)	HOMO SAPIENS (HUMAN)	HME, MATRIX METALLOPROTEINASE-12, MMP-12, MACROPHAGE ELASTASE, ME
2	C, D, J (A, B)	(2R)-3-({[4-[(PYRIDIN-4-YL)PHENYL]-THIEN-2-YL}CARBOXAMIDO)(PHENYL)PROPANOIC ACID	non-polymer		428.5	3	Chemie (PF3)
3	E, K (A, B)	ACETOHYDROXAMIC ACID	non-polymer		75.1	2	Chemie (HAE)
4	F, G, L, M (A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5	H, I, N, O (A, B)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
6	P, Q (A, B)	water	water		18.0	131	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	35263.3
Non-Polymers*	Number of molecules	13
	Total formula weight	1857.6
All*	Total formula weight	37120.9

*Water molecules are not included.