1UTT
Crystal Structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MACROPHAGE METALLOELASTASE | polymer | 159 | 17631.6 | 1 | UniProt (P39900) Pfam (PF00413) | HOMO SAPIENS (HUMAN) | HME, MATRIX METALLOPROTEINASE-12, MMP-12, MACROPHAGE ELASTASE, ME |
| 2 | B (A) | ACETOHYDROXAMIC ACID | non-polymer | 75.1 | 1 | Chemie (HAE) | |||
| 3 | C (A) | 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL) ETHYL-4-(4'-ETHOXY [1,1'-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID | non-polymer | 372.4 | 1 | Chemie (CP8) | |||
| 4 | D, E (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | F, G, H, I (A) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 6 | J (A) | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17631.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 738.6 | |
| All* | Total formula weight | 18370.3 |
