2WMW

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

2WMW の概要

• エントリーDOI: 10.2210/pdb2wmw/pdb
• 関連するPDBエントリー: 1IA8 1NVQ 1NVR 1NVS 1ZLT 1ZYS 2AYP 2BR1 2BRB 2BRG 2BRH 2BRM 2BRN 2BRO 2C3J 2C3K 2C3L 2CGU 2CGV 2CGW 2CGX 2WMQ 2WMR 2WMS 2WMT 2WMU 2WMV 2WMX
• 分子名称: SERINE/THREONINE-PROTEIN KINASE CHK1, 1-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE (3 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, polymorphism, phosphoprotein, ubl conjugation, isopeptide bond, checkpoint kinase, nucleotide-binding, serine/threonine kinase, dna damage, dna repair, atp-binding, transferase, chk1, kinase, nucleus, cytoplasm, cell cycle
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus: O14757
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33355.15

構造登録者

Matthews, T.P.,Klair, S.,Burns, S.,Boxall, K.,Cherry, M.,Fisher, M.,Westwood, I.M.,Walton, M.I.,McHardy, T.,Cheung, K.-M.J.,Van Montfort, R.,Williams, D.,Aherne, G.W.,Garrett, M.D.,Reader, J.,Collins, I. (登録日: 2009-07-03, 公開日: 2009-07-28, 最終更新日: 2023-12-13)

• 主引用文献: Matthews, T.P.,Klair, S.,Burns, S.,Boxall, K.,Cherry, M.,Fisher, M.,Westwood, I.M.,Walton, M.I.,Mchardy, T.,Cheung, K.-M.J.,Van Montfort, R.,Williams, D.,Aherne, G.W.,Garrett, M.D.,Reader, J.,Collins, I.; Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening.; J.Med.Chem., 52:4810-, 2009; PubMed: 19572549; DOI: 10.1021/JM900314J

実験手法

X-RAY DIFFRACTION (2.43 Å)