2WIN
C3 convertase (C3bBb) stabilized by SCIN
Summary for 2WIN
Entry DOI | 10.2210/pdb2win/pdb |
Related | 1DLE 1Q0P 1RRK 1RTK 2A73 2A74 2I6Q 2ICF 2QFF 2WII |
Descriptor | COMPLEMENT C3 BETA CHAIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (17 entities in total) |
Functional Keywords | serine protease, immune response, innate immunity, zymogen, secreted, protease, glycation, alternative pathway, disease mutation, hydrolase, convertase, complement, polymorphism, immune evasion, immune system |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Secreted: P01024 P01024 Q6GFB4 |
Total number of polymer chains | 16 |
Total formula weight | 984828.88 |
Authors | Wu, J.,Janssen, B.J.,Gros, P. (deposition date: 2009-05-13, release date: 2009-06-09, Last modification date: 2023-12-13) |
Primary citation | Rooijakkers, S.H.,Wu, J.,Ruyken, M.,van Domselaar, R.,Planken, K.L.,Tzekou, A.,Ricklin, D.,Lambris, J.D.,Janssen, B.J.,van Strijp, J.A.,Gros, P. Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nat. Immunol., 10:721-727, 2009 Cited by PubMed: 19503103DOI: 10.1038/ni.1756 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.9 Å) |
Structure validation
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