2VH0

Structure and property based design of factor Xa inhibitors:biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs

2VH0 の概要

• エントリーDOI: 10.2210/pdb2vh0/pdb
• 関連するPDBエントリー: 1C5M 1EZQ 1F0R 1F0S 1FAX 1FJS 1G2L 1G2M 1HCG 1IOE 1IQE 1IQF 1IQG 1IQH 1IQI 1IQJ 1IQK 1IQL 1IQM 1IQN 1KSN 1KYE 1LPG 1LPK 1LPZ 1LQD 1MQ5 1MQ6 1MSX 1NFU 1NFW 1NFX 1NFY 1NL8 1P0S 1V3X 1WU1 1XKA 1XKB 1Z6E 2BMG 2BOH 2BOK 2BQ6 2BQ7 2BQW 2CJI 2FZZ 2G00 2GD4 2J2U 2J34 2J38 2J4I 2J94 2J95 2UWL 2UWO 2UWP
• 分子名称: ACTIVATED FACTOR XA HEAVY CHAIN, ACTIVATED FACTOR XA LIGHT CHAIN, CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: serine protease, egf-like domain, blood coagulation, polymorphism, glycoprotein, hydroxylation, gamma-carboxyglutamic acid, calcium, zymogen, complex, protease, hydrolase, cleavage on pair of basic residues
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44351.82

構造登録者

Young, R.J.,Borthwick, A.D.,Brown, D.,Burns-Kurtis, C.L.,Campbell, M.,Chan, C.,Charbaut, M.,Convery, M.A.,Diallo, H.,Hortense, E.,Irving, W.R.,Kelly, H.A.,King, N.P.,Kleanthous, S.,Mason, A.M.,Pateman, A.J.,Patikis, A.,Pinto, I.L.,Pollard, D.R.,Senger, S.,Shah, G.P.,Toomey, J.R.,Watson, N.S.,Weston, H.E.,Zhou, P. (登録日: 2007-11-16, 公開日: 2008-11-25, 最終更新日: 2019-05-08)

• 主引用文献: Young, R.J.,Borthwick, A.D.,Brown, D.,Burns-Kurtis, C.L.,Campbell, M.,Chan, C.,Charbaut, M.,Convery, M.A.,Diallo, H.,Hortense, E.,Irving, W.R.,Kelly, H.A.,King, N.P.,Kleanthous, S.,Mason, A.M.,Pateman, A.J.,Patikis, A.N.,Pinto, I.L.,Pollard, D.R.,Senger, S.,Shah, G.P.,Toomey, J.R.,Watson, N.S.,Weston, H.E.,Zhou, P.; Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs.; Bioorg. Med. Chem. Lett., 18:28-33, 2008; PubMed: 18053714; DOI: 10.1016/j.bmcl.2007.11.019

実験手法

X-RAY DIFFRACTION (1.7 Å)