2VCJ

4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

2VCJ の概要

• エントリーDOI: 10.2210/pdb2vcj/pdb
• 関連するPDBエントリー: 1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2CDD 2UWD 2VCI
• 分子名称: HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide (3 entities in total)
• 機能のキーワード: alternative splicing, atp-binding, phosphorylation, cytoplasm, chaperone, stress response, nucleotide-binding
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : P07900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27059.68

構造登録者

Brough, P.A.,Aherne, W.,Barril, X.,Borgognoni, J.,Boxal, K.,Cansfield, J.E.,Cheung, K.M.,Collins, I.,Davies, N.G.M.,Drysdale, M.J.,Dymock, B.,Eccles, S.A.,Finch, H.,Fink, A.,Hayes, A.,Howes, R.,Hubbard, R.E.,James, K.,Jordan, A.M.,Lockie, A.,Martins, V.,Massey, A.,Matthews, T.P.,McDonald, E.,Northfield, C.J.,Pearl, L.H.,Prodromou, C.,Ray, S.,Raynaud, F.I.,Roughley, S.D.,Sharp, S.Y.,Surgenor, A.,Walmsley, D.L.,Webb, P.,Wood, M.,Workman, P.,Wright, L. (登録日: 2007-09-24, 公開日: 2007-12-11, 最終更新日: 2023-12-13)

• 主引用文献: Brough, P.A.,Aherne, W.,Barril, X.,Borgognoni, J.,Boxall, K.,Cansfield, J.E.,Cheung, K.M.,Collins, I.,Davies, N.G.,Drysdale, M.J.,Dymock, B.,Eccles, S.A.,Finch, H.,Fink, A.,Hayes, A.,Howes, R.,Hubbard, R.E.,James, K.,Jordan, A.M.,Lockie, A.,Martins, V.,Massey, A.,Matthews, T.P.,McDonald, E.,Northfield, C.J.,Pearl, L.H.,Prodromou, C.,Ray, S.,Raynaud, F.I.,Roughley, S.D.,Sharp, S.Y.,Surgenor, A.,Walmsley, D.L.,Webb, P.,Wood, M.,Workman, P.,Wright, L.; 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.; J. Med. Chem., 51:196-218, 2008; PubMed: 18020435; DOI: 10.1021/jm701018h

実験手法

X-RAY DIFFRACTION (2.5 Å)