2UWD

Inhibition of the HSP90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole, isoxazole amide analogs

Summary for 2UWD

Related1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2CDD 2FWY 2FWZ
DescriptorHEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION, SULFATE ION, ... (5 entities in total)
Functional Keywordschaperone, heat shock, atp-binding, phosphorylation, nucleotide-binding
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus  P07900
Total number of polymer chains1
Total molecular weight27135.25
Authors
Primary citation
Sharp, S.Y.,Prodromou, C.,Boxall, K.,Powers, M.V.,Holmes, J.L.,Box, G.,Matthews, T.P.,Cheung, K.M.,Kalusa, A.,James, K.,Hayes, A.,Hardcastle, A.,Dymock, B.,Brough, P.A.,Barril, X.,Cansfield, J.E.,Wright, L.,Surgenor, A.,Foloppe, N.,Hubbard, R.E.,Aherne, W.,Pearl, L.,Jones, K.,McDonald, E.,Raynaud, F.,Eccles, S.,Drysdale, M.,Workman, P.
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Mol. Cancer Ther., 6:1198-1211, 2007
PubMed: 17431102 (PDB entries with the same primary citation)
DOI: 10.1158/1535-7163.MCT-07-0149
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers401.1%4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 2uwd
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Molmil generated image of 2uwd
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2uwd.pdb1.gz [80.61 KB])