2V0T

The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM

Summary for 2V0T

Entry DOI	10.2210/pdb2v0t/pdb
Related	1AG1 1DKW 1IIG 1IIH 1KV5 1ML1 1MSS 1MTM 1TPD 1TPE 1TPF 1TRD 1TRI 1TSI 1TTI 1TTJ 2J24 2J27 3TIM 4TIM 5TIM 6TIM
Descriptor	TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL, SULFATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	isomerase, somerase, tim-barrel
Biological source	TRYPANOSOMA BRUCEI BRUCEI
Total number of polymer chains	8
Total formula weight	216700.54
Authors	Alahuhta, M.,Casteleijn, M.G.,Neubauer, P.,Wierenga, R.K. (deposition date: 2007-05-18, release date: 2008-02-19, Last modification date: 2023-12-13)
Primary citation	Alahuhta, M.,Casteleijn, M.G.,Neubauer, P.,Wierenga, R.K. Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM. Acta Crystallogr. D Biol. Crystallogr., 64:178-188, 2008 Cited by PubMed: 18219118 DOI: 10.1107/S0907444907059021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation