2V0T

The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM

Summary for 2V0T

Related1AG1 1DKW 1IIG 1IIH 1KV5 1ML1 1MSS 1MTM 1TPD 1TPE 1TPF 1TRD 1TRI 1TSI 1TTI 1TTJ 2J24 2J27 3TIM 4TIM 5TIM 6TIM
DescriptorTRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL, SULFATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywordsisomerase, somerase, tim-barrel
Biological sourceTRYPANOSOMA BRUCEI BRUCEI
Total number of polymer chains8
Total molecular weight216700.54
Authors
Alahuhta, M.,Casteleijn, M.G.,Neubauer, P.,Wierenga, R.K. (deposition date: 2007-05-18, release date: 2008-02-19, Last modification date: 2018-06-20)
Primary citation
Alahuhta, M.,Casteleijn, M.G.,Neubauer, P.,Wierenga, R.K.
Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM.
Acta Crystallogr. D Biol. Crystallogr., 64:178-188, 2008
PubMed: 18219118 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444907059021
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2376 0.2% 5.8% 0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171313
PDB entries from 2020-11-18