2V0T
The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL | polymer | 250 | 26907.9 | 8 | UniProt (P04789) Pfam (PF00121) In PDB | TRYPANOSOMA BRUCEI BRUCEI | TIM, TRIOSE- PHOSPHATE ISOMERASE |
| 2 | A, B, C, D, E... | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 3 | C, D | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 2 | Chemie (EPE) | |||
| 4 | water | water | 18.0 | 1469 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 250 (UniProt: P04789)
| PDB | External Database | Details |
|---|---|---|
| Leu 178 | Ala 178 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 215263.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1437.2 | |
| All* | Total formula weight | 216700.5 |
