2V0T
The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004807 | molecular_function | triose-phosphate isomerase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006094 | biological_process | gluconeogenesis |
A | 0006096 | biological_process | glycolytic process |
A | 0016853 | molecular_function | isomerase activity |
A | 0019563 | biological_process | glycerol catabolic process |
A | 0020015 | cellular_component | glycosome |
A | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
B | 0004807 | molecular_function | triose-phosphate isomerase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006094 | biological_process | gluconeogenesis |
B | 0006096 | biological_process | glycolytic process |
B | 0016853 | molecular_function | isomerase activity |
B | 0019563 | biological_process | glycerol catabolic process |
B | 0020015 | cellular_component | glycosome |
B | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
C | 0004807 | molecular_function | triose-phosphate isomerase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006094 | biological_process | gluconeogenesis |
C | 0006096 | biological_process | glycolytic process |
C | 0016853 | molecular_function | isomerase activity |
C | 0019563 | biological_process | glycerol catabolic process |
C | 0020015 | cellular_component | glycosome |
C | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
D | 0004807 | molecular_function | triose-phosphate isomerase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006094 | biological_process | gluconeogenesis |
D | 0006096 | biological_process | glycolytic process |
D | 0016853 | molecular_function | isomerase activity |
D | 0019563 | biological_process | glycerol catabolic process |
D | 0020015 | cellular_component | glycosome |
D | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
E | 0004807 | molecular_function | triose-phosphate isomerase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0006094 | biological_process | gluconeogenesis |
E | 0006096 | biological_process | glycolytic process |
E | 0016853 | molecular_function | isomerase activity |
E | 0019563 | biological_process | glycerol catabolic process |
E | 0020015 | cellular_component | glycosome |
E | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
F | 0004807 | molecular_function | triose-phosphate isomerase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0006094 | biological_process | gluconeogenesis |
F | 0006096 | biological_process | glycolytic process |
F | 0016853 | molecular_function | isomerase activity |
F | 0019563 | biological_process | glycerol catabolic process |
F | 0020015 | cellular_component | glycosome |
F | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
G | 0004807 | molecular_function | triose-phosphate isomerase activity |
G | 0005737 | cellular_component | cytoplasm |
G | 0005829 | cellular_component | cytosol |
G | 0006094 | biological_process | gluconeogenesis |
G | 0006096 | biological_process | glycolytic process |
G | 0016853 | molecular_function | isomerase activity |
G | 0019563 | biological_process | glycerol catabolic process |
G | 0020015 | cellular_component | glycosome |
G | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
H | 0004807 | molecular_function | triose-phosphate isomerase activity |
H | 0005737 | cellular_component | cytoplasm |
H | 0005829 | cellular_component | cytosol |
H | 0006094 | biological_process | gluconeogenesis |
H | 0006096 | biological_process | glycolytic process |
H | 0016853 | molecular_function | isomerase activity |
H | 0019563 | biological_process | glycerol catabolic process |
H | 0020015 | cellular_component | glycosome |
H | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A1251 |
Chain | Residue |
A | SER213 |
A | GLY234 |
A | GLY235 |
A | HOH2203 |
A | HOH2204 |
A | HOH2205 |
A | HOH2206 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 B1251 |
Chain | Residue |
B | GLY235 |
B | HOH2175 |
B | HOH2194 |
B | HOH2195 |
B | HOH2196 |
B | SER213 |
B | GLY234 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 C1251 |
Chain | Residue |
C | TRP170 |
C | SER213 |
C | GLY234 |
C | GLY235 |
C | HOH2195 |
C | HOH2196 |
C | HOH2197 |
C | HOH2198 |
site_id | AC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SO4 D1251 |
Chain | Residue |
D | SER213 |
D | GLY234 |
D | GLY235 |
D | HOH2007 |
D | HOH2205 |
D | HOH2210 |
D | HOH2211 |
D | HOH2212 |
D | HOH2213 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 E1251 |
Chain | Residue |
E | SER213 |
E | GLY234 |
E | GLY235 |
E | HOH2176 |
E | HOH2191 |
E | HOH2202 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 F1251 |
Chain | Residue |
F | GLY234 |
F | GLY235 |
F | HOH2183 |
F | HOH2184 |
F | HOH2185 |
F | HOH2186 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 G1251 |
Chain | Residue |
G | GLY235 |
G | HOH2007 |
G | HOH2116 |
G | HOH2126 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 H1251 |
Chain | Residue |
H | SER213 |
H | GLY234 |
H | GLY235 |
H | HOH2123 |
H | HOH2132 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A1252 |
Chain | Residue |
A | THR31 |
A | SER32 |
A | ILE33 |
A | HIS57 |
A | LYS59 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 E1252 |
Chain | Residue |
E | THR31 |
E | SER32 |
E | ILE33 |
E | HIS57 |
E | HOH2205 |
E | HOH2206 |
site_id | BC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EPE C1252 |
Chain | Residue |
C | LYS155 |
C | HOH2200 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EPE D1252 |
Chain | Residue |
D | ASN29 |
D | THR31 |
D | SER32 |
D | ILE33 |
D | HIS57 |
D | LYS59 |
Functional Information from PROSITE/UniProt
site_id | PS00171 |
Number of Residues | 11 |
Details | TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG |
Chain | Residue | Details |
A | ALA165-GLY175 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | ACT_SITE: Electrophile |
Chain | Residue | Details |
A | HIS95 | |
B | HIS95 | |
C | HIS95 | |
D | HIS95 | |
E | HIS95 | |
F | HIS95 | |
G | HIS95 | |
H | HIS95 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | GLU167 | |
B | GLU167 | |
C | GLU167 | |
D | GLU167 | |
E | GLU167 | |
F | GLU167 | |
G | GLU167 | |
H | GLU167 |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | BINDING: |
Chain | Residue | Details |
A | ASN11 | |
E | LYS13 | |
F | ASN11 | |
F | LYS13 | |
G | ASN11 | |
G | LYS13 | |
H | ASN11 | |
H | LYS13 | |
A | LYS13 | |
B | ASN11 | |
B | LYS13 | |
C | ASN11 | |
C | LYS13 | |
D | ASN11 | |
D | LYS13 | |
E | ASN11 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1hti |
Chain | Residue | Details |
A | LYS13 | |
A | HIS95 | |
A | ASN11 | |
A | GLU167 |
site_id | CSA2 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1hti |
Chain | Residue | Details |
B | LYS13 | |
B | HIS95 | |
B | ASN11 | |
B | GLU167 | |
B | GLY173 |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1hti |
Chain | Residue | Details |
C | LYS13 | |
C | HIS95 | |
C | ASN11 | |
C | GLU167 |
site_id | CSA4 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1hti |
Chain | Residue | Details |
D | LYS13 | |
D | HIS95 | |
D | ASN11 | |
D | GLU167 | |
D | GLY173 |
site_id | CSA5 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1hti |
Chain | Residue | Details |
E | LYS13 | |
E | HIS95 | |
E | ASN11 | |
E | GLU167 |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1hti |
Chain | Residue | Details |
F | LYS13 | |
F | HIS95 | |
F | ASN11 | |
F | GLU167 |
site_id | CSA7 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1hti |
Chain | Residue | Details |
G | LYS13 | |
G | HIS95 | |
G | ASN11 | |
G | GLU167 | |
G | GLY173 |
site_id | CSA8 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1hti |
Chain | Residue | Details |
H | LYS13 | |
H | HIS95 | |
H | ASN11 | |
H | GLU167 |