1TSI

STRUCTURE OF THE COMPLEX BETWEEN TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AND N-HYDROXY-4-PHOSPHONO-BUTANAMIDE: BINDING AT THE ACTIVE SITE DESPITE AN "OPEN" FLEXIBLE LOOP

Summary for 1TSI

DescriptorTRIOSEPHOSPHATE ISOMERASE, N-HYDROXY-4-PHOSPHONO-BUTANAMIDE (3 entities in total)
Functional Keywordsisomerase(intramolecular oxidoreductase)
Biological sourceTrypanosoma brucei brucei
Cellular locationGlycosome P04789
Total number of polymer chains2
Total molecular weight54084.98
Authors
Verlinde, C.L.M.J. (deposition date: 1992-11-19, release date: 1994-01-31, Last modification date: 2011-07-13)
Primary citation
Verlinde, C.L.,Witmans, C.J.,Pijning, T.,Kalk, K.H.,Hol, W.G.,Callens, M.,Opperdoes, F.R.
Structure of the complex between trypanosomal triosephosphate isomerase and N-hydroxy-4-phosphono-butanamide: binding at the active site despite an "open" flexible loop conformation.
Protein Sci., 1:1578-1584, 1992
PubMed: 1304889 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.84 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers39 1.8% 18.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171313
PDB entries from 2020-11-18