2V0T

The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM

2V0T の概要

• エントリーDOI: 10.2210/pdb2v0t/pdb
• 関連するPDBエントリー: 1AG1 1DKW 1IIG 1IIH 1KV5 1ML1 1MSS 1MTM 1TPD 1TPE 1TPF 1TRD 1TRI 1TSI 1TTI 1TTJ 2J24 2J27 3TIM 4TIM 5TIM 6TIM
• 分子名称: TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL, SULFATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
• 機能のキーワード: isomerase, somerase, tim-barrel
• 由来する生物種: TRYPANOSOMA BRUCEI BRUCEI
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 216700.54

構造登録者

Alahuhta, M.,Casteleijn, M.G.,Neubauer, P.,Wierenga, R.K. (登録日: 2007-05-18, 公開日: 2008-02-19, 最終更新日: 2023-12-13)

• 主引用文献: Alahuhta, M.,Casteleijn, M.G.,Neubauer, P.,Wierenga, R.K.; Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM.; Acta Crystallogr. D Biol. Crystallogr., 64:178-188, 2008; PubMed: 18219118; DOI: 10.1107/S0907444907059021

実験手法

X-RAY DIFFRACTION (2.2 Å)