Crystal structure of HRAS(G12V) - anti-RAS Fv complex

Summary for 2UZI

Related121P 1AA9 1AGP 1BKD 1CLU 1CRP 1CRQ 1CRR 1CTQ 1GNP 1GNQ 1GNR 1HE8 1IAQ 1IOZ 1JAH 1JAI 1K8R 1LF0 1LF5 1LFD 1NVU 1NVV 1NVW 1NVX 1P2S 1P2T 1P2U 1P2V 1PLJ 1PLK 1PLL 1Q21 1QRA 1RVD 1WQ1 1XCM 1XD2 1XJ0 1ZVQ 1ZW6 221P 2C5L 2CE2 2CL0 2CL6 2CL7 2CLC 2CLD 2EVW 2GDP 2Q21 421P 4Q21 521P 5P21 621P 6Q21 721P 821P
DescriptorANTI-RAS FV HEAVY CHAIN, ANTI-RAS FV LIGHT CHAIN, GTPASE HRAS, ... (7 entities in total)
Functional Keywordssignal transduction, immunoglobulin domain, membrane, antibody, oncogene, palmitate, intrabody, disease mutation, nucleotide-binding, proto-oncogene, cancer therapy, golgi apparatus, prenylation, methylation, lipoprotein, gtp- binding, signaling protein/immune system, signaling protein-immune system complex
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCell membrane. Isoform 2: Nucleus P01112
Total number of polymer chains3
Total molecular weight43700.55
Tanaka, T.,williams, R.L.,Rabbitts, T.H. (deposition date: 2007-04-27, release date: 2007-06-26, Last modification date: 2018-01-24)
Primary citation
Tanaka, T.,Williams, R.L.,Rabbitts, T.H.
Tumour Prevention by a Single Antibody Domain Targeting the Interaction of Signal Transduction Proteins with Ras.
Embo J., 26:3250-, 2007
PubMed: 17568777 (PDB entries with the same primary citation)
DOI: 10.1038/SJ.EMBOJ.7601744
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers1304.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2uzi
no rotation
Molmil generated image of 2uzi
rotated about x axis by 90°
Molmil generated image of 2uzi
rotated about y axis by 90°
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