1NVU

Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS

Summary for 1NVU
Related1BDK 1NVV 1NVW 1NVX
DescriptorTransforming protein p21/H-RAS-1, Son of sevenless protein homolog 1, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordsproto-oncogene, gtp binding, guanine nucleotide release factor, signaling protein
Biological sourceHomo sapiens (human)
More
Cellular locationCell membrane; Lipid-anchor; Cytoplasmic side: P01112
Total number of polymer chains3
Total formula weight95277.40
Authors
Margarit, S.M.,Sondermann, H.,Hall, B.E.,Nagar, B.,Hoelz, A.,Pirruccello, M.,Bar-Sagi, D.,Kuriyan, J. (deposition date: 2003-02-04, release date: 2003-04-01, Last modification date: 2011-07-13)
Primary citationBar-Sagi, D.,Hall, B.E.,Hoelz, A.,Kuriyan, J.,Margarit, S.M.,Nagar, B.,Pirruccello, M.,Sondermann, H.
Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
Cell(Cambridge,Mass.), 112:685-695, 2003
PubMed: 12628188
DOI: 110.1016/S0092-8674(03)00149-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation
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PDB entries from 2021-06-16