1NVU

Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS

Summary for 1NVU

Related1BDK 1NVV 1NVW 1NVX
DescriptorTransforming protein p21/H-RAS-1, Son of sevenless protein homolog 1, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordsproto-oncogene, gtp binding, guanine nucleotide release factor, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Lipid-anchor; Cytoplasmic side P01112
Total number of polymer chains3
Total molecular weight95277.4
Authors
Margarit, S.M.,Sondermann, H.,Hall, B.E.,Nagar, B.,Hoelz, A.,Pirruccello, M.,Bar-Sagi, D.,Kuriyan, J. (deposition date: 2003-02-04, release date: 2003-04-01, Last modification date: 2011-07-13)
Primary citation
Margarit, S.M.,Sondermann, H.,Hall, B.E.,Nagar, B.,Hoelz, A.,Pirruccello, M.,Bar-Sagi, D.,Kuriyan, J.
Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
Cell(Cambridge,Mass.), 112:685-695, 2003
PubMed: 12628188 (PDB entries with the same primary citation)
DOI: 10.1016/S0092-8674(03)00149-1
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
NMR Information
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21180.3%3.7%3.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1nvu
no rotation
Molmil generated image of 1nvu
rotated about x axis by 90°
Molmil generated image of 1nvu
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 1nvu
no rotation
Molmil generated image of 1nvu
rotated about x axis by 90°
Molmil generated image of 1nvu
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1nvu.pdb1.gz [144.45 KB])
Coordinate files for Biological unit (1nvu.pdb2.gz [568.31 KB])
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2018 Protein Data Bank Japan