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1NVU

Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS

Functional Information from GO Data
ChainGOidnamespacecontents
Q0003924molecular_functionGTPase activity
Q0005525molecular_functionGTP binding
Q0007165biological_processsignal transduction
Q0016020cellular_componentmembrane
R0003924molecular_functionGTPase activity
R0005525molecular_functionGTP binding
R0007165biological_processsignal transduction
R0016020cellular_componentmembrane
S0005085molecular_functionguanyl-nucleotide exchange factor activity
S0007264biological_processsmall GTPase-mediated signal transduction
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG Q 1002
ChainResidue
QSER17
QTHR35
QGTP1001
QHOH1008
QHOH1011

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PO4 R 1003
ChainResidue
RSER17
RGLY59
RGLU62
RHOH1074
RGLY13
RVAL14
RGLY15
RLYS16

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PO4 S 1047
ChainResidue
SHOH127
SHOH363
SARG625
SHIS695
SHIS699
SHIS700

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE PO4 S 1048
ChainResidue
RGLU63
RSER127
RARG128
RGLN131
RHOH1028
SHOH372
SHOH384
SLYS814
SGLU815
SARG826

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PO4 S 1049
ChainResidue
SHOH115
SARG660
STYR709
SGLU716
SHIS951

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 Q 1007
ChainResidue
QGLU153
QASP154
QTYR157
QARG161

site_idAC7
Number of Residues26
DetailsBINDING SITE FOR RESIDUE GTP Q 1001
ChainResidue
QGLY12
QGLY13
QVAL14
QGLY15
QLYS16
QSER17
QALA18
QPHE28
QVAL29
QASP30
QTYR32
QPRO34
QTHR35
QGLY60
QGLU62
QASN116
QLYS117
QASP119
QLEU120
QSER145
QALA146
QLYS147
QMG1002
QHOH1008
QHOH1011
QHOH1019

Functional Information from PROSITE/UniProt
site_idPS00720
Number of Residues34
DetailsRASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK
ChainResidueDetails
SVAL927-LYS960

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:16698776
ChainResidueDetails
QGLY13
RSER145
QVAL29
QGLY59
QASN116
QSER145
RGLY13
RVAL29
RGLY59
RASN116

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12
ChainResidueDetails
QMET1
RMET1

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12
ChainResidueDetails
QTHR2
RTHR2

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:9020151
ChainResidueDetails
QCYS118
RCYS118

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667
ChainResidueDetails
QTHR35
RTHR35

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
QGLN61

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
RGLN61

227561

PDB entries from 2024-11-20

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