1NVU
Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | Q, R | Transforming protein p21/H-RAS-1 | polymer | 166 | 18861.2 | 2 | UniProt (P01112) Pfam (PF00071) In PDB | Homo sapiens (human) | C-H-RAS |
| 2 | S | Son of sevenless protein homolog 1 | polymer | 481 | 56532.7 | 1 | UniProt (Q07889) Pfam (PF00618) Pfam (PF00617) In PDB | Homo sapiens (human) | SOS-1 |
| 3 | Q | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | Q, R, S | PHOSPHATE ION | non-polymer | 95.0 | 5 | Chemie (PO4) | |||
| 5 | Q | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 6 | water | water | 18.0 | 514 | Chemie (HOH) |
Sequence modifications
Q, R: 1 - 166 (UniProt: P01112)
| PDB | External Database | Details |
|---|---|---|
| Gly 59 | Ala 59 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 94255.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1022.3 | |
| All* | Total formula weight | 95277.4 |
