1NVU
Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (Q, R) | Transforming protein p21/H-RAS-1 | polymer | 166 | 18861.2 | 2 | UniProt (P01112) Pfam (PF00071) | Homo sapiens (human) | C-H-RAS |
| 2 | C (S) | Son of sevenless protein homolog 1 | polymer | 481 | 56532.7 | 1 | UniProt (Q07889) Pfam (PF00618) Pfam (PF00617) | Homo sapiens (human) | SOS-1 |
| 3 | D (Q) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 4 | E, G, H, I, J (Q, R, S) | PHOSPHATE ION | non-polymer | 95.0 | 5 | Chemie (PO4) PubChem (1061) | |||
| 5 | F (Q) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 6 | K, L, M (Q, R, S) | water | water | 18.0 | 514 | Chemie (HOH) |
Sequence modifications
Q, R: 1 - 166 (UniProt: P01112)
| PDB | External Database | Details |
|---|---|---|
| Gly 59 | Ala 59 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 94255.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1022.3 | |
| All* | Total formula weight | 95277.4 |
