2UZI
Crystal structure of HRAS(G12V) - anti-RAS Fv complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | ANTI-RAS FV HEAVY CHAIN | polymer | 114 | 12688.2 | 1 | HOMO SAPIENS (HUMAN) | ||
| 2 | B (L) | ANTI-RAS FV LIGHT CHAIN | polymer | 104 | 11220.5 | 1 | HOMO SAPIENS (HUMAN) | ||
| 3 | C (R) | GTPASE HRAS | polymer | 166 | 18917.3 | 1 | UniProt (P01112) Pfam (PF00071) | HOMO SAPIENS (HUMAN) | H-RAS ONCOPROTEIN, TRANSFORMING PROTEIN P21, P21RAS, H-RAS-1, C-H-RAS, HA-RAS |
| 4 | D, E, H, I, J (H, R) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 5 | F (R) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 6 | G (R) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 7 | K, L, M (H, L, R) | water | water | 18.0 | 289 | Chemie (HOH) |
Sequence modifications
R: 1 - 166 (UniProt: P01112)
| PDB | External Database | Details |
|---|---|---|
| Val 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 42826.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 874.5 | |
| All* | Total formula weight | 43700.5 |
