2UZI
Crystal structure of HRAS(G12V) - anti-RAS Fv complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | ANTI-RAS FV HEAVY CHAIN | polymer | 114 | 12688.2 | 1 | HOMO SAPIENS (HUMAN) | ||
| 2 | B (L) | ANTI-RAS FV LIGHT CHAIN | polymer | 104 | 11220.5 | 1 | HOMO SAPIENS (HUMAN) | ||
| 3 | C (R) | GTPASE HRAS | polymer | 166 | 18917.3 | 1 | UniProt (P01112) Pfam (PF00071) | HOMO SAPIENS (HUMAN) | H-RAS ONCOPROTEIN, TRANSFORMING PROTEIN P21, P21RAS, H-RAS-1, C-H-RAS, HA-RAS |
| 4 | D, E, H, I, J (H, R) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 5 | F (R) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 6 | G (R) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | K, L, M (H, L, R) | water | water | 18.0 | 289 | Chemie (HOH) |
Sequence modifications
R: 1 - 166 (UniProt: P01112)
| PDB | External Database | Details |
|---|---|---|
| Val 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 42826.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 874.5 | |
| All* | Total formula weight | 43700.5 |
