2UZI

Crystal structure of HRAS(G12V) - anti-RAS Fv complex

Functional Information from GO Data

Chain	GOid	namespace	contents
R	0003924	molecular_function	GTPase activity
R	0005525	molecular_function	GTP binding
R	0007165	biological_process	signal transduction
R	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H1115

Chain	Residue
H	ASP73
H	SER75
H	HOH2071
H	HOH2106

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN H1116

Chain	Residue
H	ASP62

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG R1168

Chain	Residue
R	HOH2049
R	SER17
R	THR35
R	GTP1167
R	HOH2022

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN R1169

Chain	Residue
R	HIS27
R	GLU98
R	HOH2127
R	HOH2128

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN R1170

Chain	Residue
R	HIS166

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN R1171

Chain	Residue
H	GLU1
R	ASP108
R	HIS166

---

site_id	AC7
Number of Residues	26
Details	BINDING SITE FOR RESIDUE GTP R1167

Chain	Residue
R	GLY13
R	VAL14
R	GLY15
R	LYS16
R	SER17
R	ALA18
R	PHE28
R	VAL29
R	ASP30
R	GLU31
R	TYR32
R	PRO34
R	THR35
R	GLY60
R	ASN116
R	LYS117
R	ASP119
R	SER145
R	ALA146
R	LYS147
R	MG1168
R	HOH2022
R	HOH2049
R	HOH2090
R	HOH2125
R	HOH2126

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:16698776

Chain	Residue	Details
R	GLY13
R	VAL29
R	ALA59
R	ASN116
R	SER145

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12

Chain	Residue	Details
R	MET1

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12

Chain	Residue	Details
R	THR2

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:9020151

Chain	Residue	Details
R	CYS118

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667

Chain	Residue	Details
R	THR35

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