1JAI

H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MANGANESE

Summary for 1JAI

• Entry DOI: 10.2210/pdb1jai/pdb
• Descriptor: C-HA-RAS, MANGANESE (II) ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... (4 entities in total)
• Functional Keywords: gtp hydrolysis, signal transduction, cancer, g-domain, gtp-binding
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Lipid-anchor; Cytoplasmic side: P01112
• Total number of polymer chains: 1
• Total formula weight: 19491.40

Authors

Schweins, T.,Scheffzek, K.,Assheuer, R.,Wittinghofer, A. (deposition date: 1996-12-15, release date: 1997-07-23, Last modification date: 2024-04-03)

• Primary citation: Schweins, T.,Scheffzek, K.,Assheuer, R.,Wittinghofer, A.; The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+.; J.Mol.Biol., 266:847-856, 1997; PubMed: 9102473; DOI: 10.1006/jmbi.1996.0814

Experimental method

X-RAY DIFFRACTION (1.8 Å)