2J21

Human p53 core domain mutant M133L-V203A-N239Y-N268D-R282W

2J21 の概要

• エントリーDOI: 10.2210/pdb2j21/pdb
• 関連するPDBエントリー: 1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2F1X 2FEJ 2J0Z 2J10 2J11 2J1W 2J1X 2J1Y 2J1Z 2J20 3SAK
• 分子名称: CELLULAR TUMOR ANTIGEN P53, ZINC ION (3 entities in total)
• 機能のキーワード: second-site suppressor mutation, disease mutation, nuclear protein, phosphorylation, tumor suppressor, alternative splicing, li-fraumeni syndrome, li- fraumeni syndrome, host-virus interaction, transcription, metal-binding, anti-oncogene, dna-binding, transferase, polymorphism, glycoprotein, zinc, activator, apoptosis, cell cycle, acetylation, p53 dna-binding domain, transcription regulation, superstable mutant, dna-binding protein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49370.53

構造登録者

Joerger, A.C.,Fersht, A.R. (登録日: 2006-08-15, 公開日: 2006-09-20, 最終更新日: 2023-12-13)

• 主引用文献: Joerger, A.C.,Ang, H.C.,Fersht, A.R.; Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.; Proc.Natl.Acad.Sci.USA, 103:15056-, 2006; PubMed: 17015838; DOI: 10.1073/PNAS.0607286103

実験手法

X-RAY DIFFRACTION (1.6 Å)