2J11

p53 tetramerization domain mutant Y327S T329G Q331G

2J11 の概要

• エントリーDOI: 10.2210/pdb2j11/pdb
• 関連するPDBエントリー: 1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2F1X 2FEJ 2J0Z 2J10 3SAK
• NMR情報: BMRB: 7252
• 分子名称: CELLULAR TUMOR ANTIGEN P53 (1 entity in total)
• 機能のキーワード: host-virus interaction, nuclear protein, phosphorylation, disease mutation, li-fraumeni syndrome, transcription regulation, transcription, metal-binding, anti-oncogene, dna-binding, glycoprotein, activator, apoptosis, cell cycle
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 14299.99

構造登録者

Carbajo, R.J.,Mora, P.,Sanchez del Pino, M.M.,Perez-Paya, E.,Pineda-Lucena, A. (登録日: 2006-08-08, 公開日: 2007-08-28, 最終更新日: 2024-05-15)

• 主引用文献: Mora, P.,Carbajo, R.J.,Pineda-Lucena, A.,Sanchez del Pino, M.M.,Perez-Paya, E.; Solvent-exposed residues located in the beta-sheet modulate the stability of the tetramerization domain of p53--a structural and combinatorial approach.; Proteins, 71:1670-1685, 2008; PubMed: 18076077; DOI: 10.1002/prot.21854

実験手法

SOLUTION NMR