2CHM

Crystal structure of N2 substituted pyrazolo pyrimidinones - a flipped binding mode in PDE5

2CHM の概要

• エントリーDOI: 10.2210/pdb2chm/pdb
• 関連するPDBエントリー: 1F0J 1JP1 1JP2 1RKP 1RO6 1RO9 1ROR 1T9R 1T9S 1TB5 1TBF 1UDT 1UDU 1UHO 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1XOZ 1XP0 1Y2H 1Y2J
• 分子名称: CGMP-SPECIFIC 3', 5'-CYCLIC PHOSPHODIESTERASE, CAMP-SPECIFIC 3', 5'-CYCLIC PHOSPHODIESTERASE 4B, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: phosphodiesterase 5, inhibitor, chimera, allosteric enzyme, alternative splicing, cgmp, cgmp-binding, hydrolase, magnesium, metal-binding, nucleotide-binding, phosphorylation, zinc, camp
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38332.68

構造登録者

Allerton, C.M.N.,Barber, C.G.,Beaumont, K.C.,Brown, D.G.,Cole, S.M.,Ellis, D.,Lane, C.A.L.,Maw, G.N.,Mount, N.M.,Rawson, D.J.,Robinson, C.M.,Street, S.D.A.,Summerhill, N.W. (登録日: 2006-03-15, 公開日: 2006-06-08, 最終更新日: 2024-05-01)

• 主引用文献: Allerton, C.M.N.,Barber, C.G.,Beaumont, K.C.,Brown, D.G.,Cole, S.M.,Ellis, D.,Lane, C.A.L.,Maw, G.N.,Mount, N.M.,Rawson, D.J.,Robinson, C.M.,Street, S.D.A.,Summerhill, N.W.; A Novel Series of Potent and Selective Pde5 Inhibitors with Potential for High and Dose-Independent Oral Bioavailability; J.Med.Chem., 49:3581-, 2006; PubMed: 16759100; DOI: 10.1021/JM060113E

実験手法

X-RAY DIFFRACTION (1.6 Å)