2C4H

Torpedo californica acetylcholinesterase in complex with 500mM acetylthiocholine

Summary for 2C4H

Entry DOI	10.2210/pdb2c4h/pdb
Related	1ACJ 1ACL 1AMN 1AX9 1CFJ 1DX6 1E3Q 1E66 1EA5 1EEA 1EVE 1FSS 1GPK 1GPN 1GQR 1GQS 1H22 1H23 1HBJ 1JGA 1JGB 1JJB 1OCE 1ODC 1QID 1QIE 1QIF 1QIG 1QIH 1QII 1QIJ 1QIK 1QIM 1QTI 1SOM 1U65 1UT6 1VOT 1VXO 1VXR 1W4L 1W6R 1W75 1W76 1ZGB 1ZGC 2ACE 2ACK 2C58 2C5F 2C5G 2DFP 3ACE 4ACE
Descriptor	ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, TRIETHYLENE GLYCOL, ... (8 entities in total)
Functional Keywords	hydrolase, serine esterase, synapse, membrane, neurotransmitter cleavage, alpha/beta hydrolase, substrate- inhibition, alternative splicing, glycoprotein, gpi-anchor, lipoprotein, neurotransmitter degradation
Biological source	TORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY)
Total number of polymer chains	1
Total formula weight	62296.90
Authors	Colletier, J.P.,Fournier, D.,Greenblatt, H.M.,Sussman, J.L.,Zaccai, G.,Silman, I.,Weik, M. (deposition date: 2005-10-19, release date: 2006-06-14, Last modification date: 2023-12-13)
Primary citation	Colletier, J.P.,Fournier, D.,Greenblatt, H.M.,Stojan, J.,Sussman, J.L.,Zaccai, G.,Silman, I.,Weik, M. Structural insights into substrate traffic and inhibition in acetylcholinesterase. EMBO J., 25:2746-2756, 2006 Cited by PubMed: 16763558 DOI: 10.1038/sj.emboj.7601175 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation