2C2K
Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors.
Summary for 2C2K
Entry DOI | 10.2210/pdb2c2k/pdb |
Related | 1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2J30 2J31 2J32 2J33 |
Related PRD ID | PRD_000330 |
Descriptor | CASPASE-3 SUBUNIT P17, CASPASE-3 SUBUNIT P12, AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-8-(2-CARBOXYETHYL)-5-(CARBOXYMETHYL)-14-(4-ETHOXY-4-OXOBUTANOYL)-11-(1-METHYLETHYL)-3,6,9,12-TETRAOXO-1-PHENYL-2-OXA-4,7,10,13,14-PENTAAZAHEXADECAN -16-OIC ACID, ... (4 entities in total) |
Functional Keywords | apoptosis, hydrolase-hydrolase inhibitor complex, cysteine-protease, ice, tetramer, thiol protease, zymogen, cpp32, yama, aza-peptide, michael acceptor, aza-asp, clan cd, hydrolase/hydrolase inhibitor |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm: P42574 P42574 |
Total number of polymer chains | 3 |
Total formula weight | 29335.70 |
Authors | Ganesan, R.,Jelakovic, S.,Ekici, O.D.,Li, Z.Z.,James, K.E.,Asgian, J.L.,Campbell, A.J.,Mikolajczyk, J.,Salvesen, G.S.,Gruetter, M.G.,Powers, J.C. (deposition date: 2005-09-29, release date: 2006-09-20, Last modification date: 2023-11-15) |
Primary citation | Ekici, O.D.,Li, Z.Z.,Campbell, A.J.,James, K.E.,Asgian, J.L.,Mikolajczyk, J.,Salvesen, G.S.,Ganesan, R.,Jelakovic, S.,Grutter, M.G.,Powers, J.C. Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10. J.Med.Chem., 49:5728-, 2006 Cited by PubMed: 16970398DOI: 10.1021/JM0601405 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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