2X81
STRUCTURE OF AURORA A IN COMPLEX WITH MLN8054
Summary for 2X81
Entry DOI | 10.2210/pdb2x81/pdb |
Related | 1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2J4Z 2J50 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D |
Descriptor | SERINE/THREONINE-PROTEIN KINASE 6, 4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID (2 entities in total) |
Functional Keywords | transferase, drug-resistance, cell cycle, cytoskeleton |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965 |
Total number of polymer chains | 1 |
Total formula weight | 31917.01 |
Authors | Savory, W.,Mueller, I.,Mason, C.S.,Lamers, M.,Williams, D.H.,Eyers, P.A. (deposition date: 2010-03-05, release date: 2010-05-05, Last modification date: 2023-12-20) |
Primary citation | Sloane, D.,Trikic, M.,Chu, M.L.,Lamers, M.,Mason, C.S.,Mueller, I.,Savory, W.,Williams, D.H.,Eyers, P.A. Drug-Resistant Aurora a Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors Mln8054 and Mln8237. Acs Chem.Biol., 5:563-, 2010 Cited by PubMed: 20426425DOI: 10.1021/CB100053Q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.91 Å) |
Structure validation
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