2VKM
Crystal structure of GRL-8234 bound to BACE (Beta-secretase)
Summary for 2VKM
Entry DOI | 10.2210/pdb2vkm/pdb |
Related | 1FKN 1M4H 1PY1 1SGZ 1TQF 1UJJ 1UJK 1W50 1W51 1XN2 1XN3 1XS7 1YM2 1YM4 2B8L 2B8V 2VA5 2VA6 2VA7 2VIE 2VIJ 2VIY 2VIZ 2VJ6 2VJ7 |
Descriptor | BETA-SECRETASE 1, N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide (3 entities in total) |
Functional Keywords | alternative splicing, aspartyl protease, aspartic protease, glycoprotein, transmembrane, beta secretase, app, bace, a-beta, x- ray, zymogen, membrane, protease, memapsin, hydrolase, alzheimer, drug design |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 4 |
Total formula weight | 175886.45 |
Authors | Hong, L.,Tang, J.,Ghosh, A.K. (deposition date: 2007-12-04, release date: 2008-12-16, Last modification date: 2023-12-13) |
Primary citation | Ghosh, A.K.,Kumaragurubaran, N.,Hong, L.,Kulkarni, S.,Xu, X.,Miller, H.B.,Reddy, D.S.,Weerasena, V.,Turner, R.,Chang, W.,Koelsch, G.,Tang, J. Potent Memapsin 2 (Beta-Secretase) Inhibitors: Design, Synthesis, Protein-Ligand X-Ray Structure, and in Vivo Evaluation. Bioorg.Med.Chem.Lett., 18:1031-, 2008 Cited by PubMed: 18180160DOI: 10.1016/J.BMCL.2007.12.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
Download full validation report