1YM2
Crystal structure of human beta secretase complexed with NVP-AUR200
Summary for 1YM2
Entry DOI | 10.2210/pdb1ym2/pdb |
Related | 1YM4 |
Related PRD ID | PRD_000291 |
Descriptor | Beta-secretase 1, NVP-AUR200 INHIBITOR (3 entities in total) |
Functional Keywords | beta-secretase, memapsin2, alzheimer's disease, aspartic protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 6 |
Total formula weight | 136335.84 |
Authors | Hanessian, S.,Yun, H.,Hou, Y.,Yang, G.,Bayrakdarian, M.,Therrien, E.,Moitessier, N.,Roggo, S.,Veenstra, S. (deposition date: 2005-01-20, release date: 2006-01-17, Last modification date: 2023-11-15) |
Primary citation | Hanessian, S.,Yun, H.,Hou, Y.,Yang, G.,Bayrakdarian, M.,Therrien, E.,Moitessier, N.,Roggo, S.,Veenstra, S.,Tintelnot-Blomley, M.,Rondeau, J.M.,Ostermeier, C.,Strauss, A.,Ramage, P.,Paganetti, P.,Neumann, U.,Betschart, C. Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics J.Med.Chem., 48:5175-5190, 2005 Cited by PubMed: 16078837DOI: 10.1021/jm050142+ PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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