1YM2
Crystal structure of human beta secretase complexed with NVP-AUR200
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Beta-secretase 1 | polymer | 402 | 44777.3 | 3 | UniProt (P56817) Pfam (PF00026) | Homo sapiens (human) | Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Aspartyl protease 2, Asp 2, ASP2, Membrane-associated aspartic protease 2, Memapsin-2 |
| 2 | D, E, F (X, Y, Z) | NVP-AUR200 INHIBITOR | polymer | 6 | 667.9 | 3 | BIRD (PRD_000291) | ||
| 3 | G, H, I, J, K... (A, B, C, X, Y...) | water | water | 18.0 | 578 | Chemie (HOH) |
Sequence modifications
A, B, C: -13 - 386 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Gly -15 | - | expression tag |
| Pro -14 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 136335.8 | |
| All* | Total formula weight | 136335.8 |
