1YM4

Crystal structure of human beta secretase complexed with NVP-AMK640

Summary for 1YM4

Entry DOI	10.2210/pdb1ym4/pdb
Related	1YM2
Related PRD ID	PRD_000292
Descriptor	Beta-secretase 1, NVP-AMK640 INHIBITOR (3 entities in total)
Functional Keywords	beta-secretase, memapsin2, alzheimer's disease, aspartic protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	6
Total formula weight	138233.09
Authors	Hanessian, S.,Yun, H.,Hou, Y.,Yang, G.,Bayrakdarian, M.,Therrien, E.,Moitessier, N.,Roggo, S.,Veenstra, S. (deposition date: 2005-01-20, release date: 2006-01-17, Last modification date: 2023-11-15)
Primary citation	Hanessian, S.,Yun, H.,Hou, Y.,Yang, G.,Bayrakdarian, M.,Therrien, E.,Moitessier, N.,Roggo, S.,Veenstra, S.,Tintelnot-Blomley, M.,Rondeau, J.M.,Ostermeier, C.,Strauss, A.,Ramage, P.,Paganetti, P.,Neumann, U.,Betschart, C. Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics J.Med.Chem., 48:5175-5190, 2005 Cited by PubMed: 16078837 DOI: 10.1021/jm050142+ PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation