1YM4
Crystal structure of human beta secretase complexed with NVP-AMK640
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Beta-secretase 1 | polymer | 408 | 45435.0 | 3 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (human) | Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Aspartyl protease 2, Asp 2, ASP2, Membrane-associated aspartic protease 2, Memapsin-2 |
| 2 | X, Y, Z | NVP-AMK640 INHIBITOR | polymer | 5 | 642.7 | 3 | BIRD (PRD_000292) | ||
| 3 | water | water | 18.0 | 487 | Chemie (HOH) |
Sequence modifications
A, B, C: -13 - 392 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Gly -15 | - | expression tag |
| Pro -14 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 138233.1 | |
| All* | Total formula weight | 138233.1 |
