1W50

Apo Structure of BACE (Beta Secretase)

Summary for 1W50

• Entry DOI: 10.2210/pdb1w50/pdb
• Related: 1FKN 1M4H 1PY1 1SGZ 1UJJ 1UJK 1W51
• Descriptor: BETA-SECRETASE 1, IODIDE ION (3 entities in total)
• Functional Keywords: alternative splicing, alzheimer's disease, aspartic protease, aspartyl protease, base, beta-secretase, glycoprotein, hydrolase, memapsin 2, transmembrane, zymogen
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Membrane; Single-pass type I membrane protein: P56817
• Total number of polymer chains: 1
• Total formula weight: 46330.06

Authors

Patel, S.,Vuillard, L.,Cleasby, A.,Murray, C.W.,Yon, J. (deposition date: 2004-08-04, release date: 2004-09-23, Last modification date: 2023-12-13)

• Primary citation: Patel, S.,Vuillard, L.,Cleasby, A.,Murray, C.W.,Yon, J.; Apo and Inhibitor Complex Structures of Bace (Beta-Secretase); J.Mol.Biol., 343:407-, 2004; PubMed: 15451669; DOI: 10.1016/J.JMB.2004.08.018

Experimental method

X-RAY DIFFRACTION (1.75 Å)