1W51
BACE (Beta Secretase) in complex with a nanomolar non-peptidic inhibitor
Summary for 1W51
Entry DOI | 10.2210/pdb1w51/pdb |
Related | 1FKN 1M4H 1PY1 1SGZ 1UJJ 1UJK 1W50 |
Descriptor | BETA-SECRETASE 1, IODIDE ION, 3-[({(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}AMINO)(HYDROXY)METHYL]-N,N-DIPROPYLBENZAMIDE, ... (4 entities in total) |
Functional Keywords | hydrolase/inhibitor, hydrolase-inhibitor complex, alternative splicing, alzheimer's disease, aspartic protease, aspartyl protease, base, beta-secretase, glycoprotein, hydrolase, memapsin 2, transmembrane, zymogen |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 46861.75 |
Authors | Patel, S.,Vuillard, L.,Cleasby, A.,Murray, C.W.,Yon, J. (deposition date: 2004-08-04, release date: 2004-09-23, Last modification date: 2023-12-13) |
Primary citation | Patel, S.,Vuillard, L.,Cleasby, A.,Murray, C.W.,Yon, J. Apo and Inhibitor Complex Structures of Bace (Beta-Secretase) J.Mol.Biol., 343:407-, 2004 Cited by PubMed: 15451669DOI: 10.1016/J.JMB.2004.08.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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