1W51
BACE (Beta Secretase) in complex with a nanomolar non-peptidic inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | BETA-SECRETASE 1 | polymer | 411 | 45822.4 | 1 | UniProt (P56817) Pfam (PF00026) | HOMO SAPIENS (HUMAN) | BETA SECRETASE, BETA-SITE APP CLEAVING ENZYME 1, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, ASPARTYL PROTEASE 2, ASP 2, ASP2, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN-2 |
| 2 | B, C, D, E (A) | IODIDE ION | non-polymer | 126.9 | 4 | Chemie (IOD) | |||
| 3 | F (A) | 3-[({(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}AMINO)(HYDROXY)METHYL]-N,N-DIPROPYLBENZAMIDE | non-polymer | 531.7 | 1 | Chemie (L01) | |||
| 4 | G (A) | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45822.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1039.3 | |
| All* | Total formula weight | 46861.7 |
