2VKM

Crystal structure of GRL-8234 bound to BACE (Beta-secretase)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	BETA-SECRETASE 1	polymer	389	43312.8	4	UniProt (P56817) Pfam (PF00026) In PDB	HOMO SAPIENS (HUMAN)	BETA-SITE APP CLEAVING ENZYME 1, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN-2, ASPARTYL PROTEASE 2, ASP 2, ASP2, BACE
2	A, B, C, D	N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide	non-polymer		658.8	4	Chemie (BSD)
3		water	water		18.0	784	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	173251.2
Non-Polymers*	Number of molecules	4
	Total formula weight	2635.2
All*	Total formula weight	175886.4

*Water molecules are not included.