2VKM
Crystal structure of GRL-8234 bound to BACE (Beta-secretase)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | BETA-SECRETASE 1 | polymer | 389 | 43312.8 | 4 | UniProt (P56817) Pfam (PF00026) | HOMO SAPIENS (HUMAN) | BETA-SITE APP CLEAVING ENZYME 1, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN-2, ASPARTYL PROTEASE 2, ASP 2, ASP2, BACE |
| 2 | E, F, G, H (A, B, C, D) | N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide | non-polymer | 658.8 | 4 | Chemie (BSD) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 784 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 173251.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2635.2 | |
| All* | Total formula weight | 175886.4 |
