1TQF
Crystal structure of human Beta secretase complexed with inhibitor
Summary for 1TQF
Entry DOI | 10.2210/pdb1tqf/pdb |
Descriptor | Beta-secretase 1, 3-{2-[(5-AMINOPENTYL)AMINO]-2-OXOETHOXY}-5-({[1-(4-FLUOROPHENYL)ETHYL]AMINO}CARBONYL)PHENYL PHENYLMETHANESULFONATE (3 entities in total) |
Functional Keywords | aspartyl protease, bace, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 45694.41 |
Authors | Munshi, S.,Chen, Z.,Kuo, L. (deposition date: 2004-06-17, release date: 2004-11-09, Last modification date: 2023-08-23) |
Primary citation | Coburn, C.A.,Stachel, S.J.,Li, Y.M.,Rush, D.M.,Steele, T.G.,Chen-Dodson, E.,Holloway, M.K.,Xu, M.,Huang, Q.,Lai, M.T.,DiMuzio, J.,Crouthamel, M.C.,Shi, X.P.,Sardana, V.,Chen, Z.,Munshi, S.,Kuo, L.,Makara, G.M.,Annis, D.A.,Tadikonda, P.K.,Nash, H.M.,Vacca, J.P.,Wang, T. Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases. J.Med.Chem., 47:6117-6119, 2004 Cited by PubMed: 15566281DOI: 10.1021/jm049388p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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