2B8L
Crystal structure of human beta secretase complexed with inhibitor
Summary for 2B8L
Entry DOI | 10.2210/pdb2b8l/pdb |
Descriptor | Beta-secretase 1, N-[(1S,2R)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2-HYDROXYPROPYL]-5-[METHYL(METHYLSULFONYL)AMINO]-N'-[(1R)-1-PHENYLETHYL]ISOPHTHALAMIDE (3 entities in total) |
Functional Keywords | aspartyl protease, bace, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 45701.47 |
Authors | Munshi, S.K.,Kuo, L. (deposition date: 2005-10-07, release date: 2005-10-18, Last modification date: 2023-08-23) |
Primary citation | Stachel, S.J.,Coburn, C.A.,Steele, T.G.,Crouthamel, M.C.,Pietrak, B.L.,Lai, M.T.,Holloway, M.K.,Munshi, S.K.,Graham, S.L.,Vacca, J.P. Conformationally biased P3 amide replacements of beta-secretase inhibitors Bioorg.Med.Chem.Lett., 16:641-644, 2006 Cited by PubMed: 16263281DOI: 10.1016/j.bmcl.2005.10.032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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