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1WBW

Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.

Summary for 1WBW
Entry DOI10.2210/pdb1wbw/pdb
Related1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WFC 1YQJ 1ZZ2 1ZZL
DescriptorMITOGEN-ACTIVATED PROTEIN KINASE 14, 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE (3 entities in total)
Functional Keywordsp38, map kinase, inhibitor structure, alternative splicing, atp-binding, nuclear protein, phosphorylation, serine/threonine protein kinase, transferase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm (By similarity): Q16539
Total number of polymer chains1
Total formula weight41593.49
Authors
Tickle, J.,Cleasby, A.,Devine, L.A.,Jhoti, H. (deposition date: 2004-11-05, release date: 2005-11-03, Last modification date: 2011-07-13)
Primary citationGill, A.,Frederickson, M.,Cleasby, A.,Woodhead, S.J.,Carr, M.G.,Woodhead, A.J.,Walker, M.T.,Congreve, M.S.,Devine, L.A.,Tisi, D.,O'Reilly, M.,Seavers, L.,Davis, D.J.,Curry, J.,Anthony, R.,Padova, A.,Murray, C.W.,Carr, R.A.E.,Jhoti, H.
Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation
J.Med.Chem., 48:414-, 2005
Cited by
PubMed: 15658855
DOI: 10.1021/JM049575N
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.41 Å)
Structure validation

217705

数据于2024-03-27公开中

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