1WBW

Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	MITOGEN-ACTIVATED PROTEIN KINASE 14	polymer	360	41343.2	1	UniProt (Q16539) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	MITOGEN-ACTIVATED PROTEIN KINASE P38ALPHA, MAP KINASE P38ALPHA, CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG BINDING PROTEIN, CSAID BINDING PROTEIN, CSBP, MAX-INTERACTING PROTEIN 2, MAP KINASE MXI2, SAPK2A
2	B (A)	3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE	non-polymer		250.3	1	Chemie (LI4)
3	C (A)	water	water		18.0	266	Chemie (HOH)

Sequence modifications

A: 1 - 1 (PDB: 1WBW)
A: 2 - 360 (UniProt: Q16539)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	41343.2
Non-Polymers*	Number of molecules	1
	Total formula weight	250.3
All*	Total formula weight	41593.5

*Water molecules are not included.