1WBW

Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.

1WBW の概要

• エントリーDOI: 10.2210/pdb1wbw/pdb
• 関連するPDBエントリー: 1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WFC 1YQJ 1ZZ2 1ZZL
• 分子名称: MITOGEN-ACTIVATED PROTEIN KINASE 14, 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE (3 entities in total)
• 機能のキーワード: p38, map kinase, inhibitor structure, alternative splicing, atp-binding, nuclear protein, phosphorylation, serine/threonine protein kinase, transferase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41593.49

構造登録者

Tickle, J.,Cleasby, A.,Devine, L.A.,Jhoti, H. (登録日: 2004-11-05, 公開日: 2005-11-03, 最終更新日: 2011-07-13)

• 主引用文献: Gill, A.,Frederickson, M.,Cleasby, A.,Woodhead, S.J.,Carr, M.G.,Woodhead, A.J.,Walker, M.T.,Congreve, M.S.,Devine, L.A.,Tisi, D.,O'Reilly, M.,Seavers, L.,Davis, D.J.,Curry, J.,Anthony, R.,Padova, A.,Murray, C.W.,Carr, R.A.E.,Jhoti, H.; Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation; J.Med.Chem., 48:414-, 2005; PubMed: 15658855; DOI: 10.1021/JM049575N

実験手法

X-RAY DIFFRACTION (2.41 Å)