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1W4L

Complex of TcAChE with bis-acting galanthamine derivative

Summary for 1W4L
Entry DOI10.2210/pdb1w4l/pdb
Related1ACJ 1ACL 1AMN 1AX9 1CFJ 1DX6 1E3Q 1E66 1EA5 1EEA 1EVE 1FSS 1GPK 1GPN 1GQR 1GQS 1H22 1H23 1HBJ 1JGA 1JGB 1JJB 1OCE 1ODC 1QID 1QIE 1QIF 1QIG 1QIH 1QII 1QIJ 1QIK 1QIM 1QTI 1SOM 1UT6 1VOT 1VXO 1VXR 1W6R 1W75 1W76 2ACE 2ACK 2DFP 3ACE 4ACE
DescriptorACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywordsalzheimer's disease, cholinesterase, glycoprotein, gpi-anchor, hydrolase, muscle, nerve, neurotransmitter degradation, serine esterase, serine hydrolase, synapse
Biological sourceTORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY)
Total number of polymer chains1
Total formula weight62721.55
Authors
Greenblatt, H.M.,Guillou, C.,Guenard, D.,Badet, B.,Thal, C.,Silman, I.,Sussman, J.L. (deposition date: 2004-07-25, release date: 2004-11-25, Last modification date: 2020-07-29)
Primary citationGreenblatt, H.M.,Guillou, C.,Guenard, D.,Argaman, A.,Botti, S.,Badet, B.,Thal, C.,Silman, I.,Sussman, J.L.
The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.
J.Am.Chem.Soc., 126:15405-15411, 2004
Cited by
PubMed: 15563167
DOI: 10.1021/ja0466154
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.16 Å)
Structure validation

217705

數據於2024-03-27公開中

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