1H23
Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(12)-hupyridone at 2.15A resolution
Summary for 1H23
Entry DOI | 10.2210/pdb1h23/pdb |
Related | 1ACJ 1ACL 1AMN 1AX9 1CFJ 1DX6 1E3Q 1E66 1EA5 1EEA 1EVE 1FSS 1GPK 1GPN 1GQR 1GQS 1H22 1HBJ 1JJB 1OCE 1QID 1QIE 1QIF 1QIG 1QIH 1QII 1QIJ 1QIK 1QIM 1QTI 1SOM 1VOT 1VXO 1VXR 2ACE 2ACK 2DFP 3ACE 4ACE |
Descriptor | ACETYLCHOLINESTERASE, (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,12-DIAMINODODECANE DIHYDROCHLORIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | serine hydrolase, acetylcholinesterase, neurotransmitter cleavage, alzheimer's disease, bivalent ligand, dual-site binding, inhibitor, huperzine a, hydrolase, serine esterase synapse, membrane, nerve, muscle, gpi-anchor neurotransmitter degradation, glycoprotein, bis(12)-hupyrid |
Biological source | TORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY) |
Total number of polymer chains | 1 |
Total formula weight | 62262.22 |
Authors | Wong, D.M.,Greenblatt, H.M.,Carlier, P.R.,Han, Y.F.,Pang, Y.P.,Silman, I.,Sussman, J.L. (deposition date: 2002-07-30, release date: 2002-12-23, Last modification date: 2023-12-13) |
Primary citation | Wong, D.M.,Greenblatt, H.M.,Dvir, H.,Carlier, P.R.,Han, Y.F.,Pang, Y.P.,Silman, I.,Sussman, J.L. Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity J.Am.Chem.Soc., 125:363-, 2003 Cited by PubMed: 12517147DOI: 10.1021/JA021111W PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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