1H22

Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(10)-hupyridone at 2.15A resolution

Summary for 1H22

• Entry DOI: 10.2210/pdb1h22/pdb
• Related: 1ACJ 1ACL 1AMN 1AX9 1CFJ 1DX6 1E3Q 1E66 1EA5 1EEA 1EVE 1FSS 1GPK 1GPN 1GQR 1GQS 1H23 1HBJ 1JJB 1OCE 1QID 1QIE 1QIF 1QIG 1QIH 1QII 1QIJ 1QIK 1QIM 1QTI 1SOM 1VOT 1VXO 1VXR 2ACE 2ACK 2DFP 3ACE 4ACE
• Descriptor: ACETYLCHOLINESTERASE, (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,10-DIAMINODECANE DIHYDROCHLORIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: serine hydrolase, acetylcholinesterase, neurotransmitter cleavage, alzheimer's disease, bivalent ligand, dual-site binding, inhibitor, huperzine a, hydrolase, serine esterase synapse, membrane, nerve, muscle, gpi-anchor neurotransmitter degradation, glycoprotein, bis(10)-hupyrid
• Biological source: TORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY)
• Total number of polymer chains: 1
• Total formula weight: 62234.16

Authors

Wong, D.M.,Greenblatt, H.M.,Carlier, P.R.,Han, Y.-F.,Pang, Y.-P.,Silman, I.,Sussman, J.L. (deposition date: 2002-07-30, release date: 2002-12-23, Last modification date: 2023-12-13)

• Primary citation: Wong, D.M.,Greenblatt, H.M.,Dvir, H.,Carlier, P.R.,Han, Y.-F.,Pang, Y.-P.,Silman, I.,Sussman, J.L.; Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity; J.Am.Chem.Soc., 125:363-, 2003; PubMed: 12517147; DOI: 10.1021/JA021111W

Experimental method

X-RAY DIFFRACTION (2.15 Å)