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8FEY
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BU of 8fey by Molmil
Solution structure of Pmu1a
Descriptor: Pmu1a toxin
Authors:Daly, N.L, Wilson, D.T.
Deposit date:2022-12-07
Release date:2023-03-29
Last modified:2023-08-02
Method:SOLUTION NMR
Cite:Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNa V 1.7 and hCa V 3 voltage-gated channels.
Febs J., 290, 2023
8FD4
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BU of 8fd4 by Molmil
Solution structure of mu-theraphotoxin Cg4a from Chinese tarantula Chilobrachys jingzhao
Descriptor: Jingzhaotoxin F7-10.36
Authors:Sharma, G, Jia, X, Chin, Y.K.Y, Mobli, M.
Deposit date:2022-12-01
Release date:2023-11-08
Method:SOLUTION NMR
Cite:Solution structure of mu-theraphotoxin Cg4a from Chinese tarantula Chilobrachys jingzhao
To Be Published
8CJT
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BU of 8cjt by Molmil
JzTx-34 toxin peptide W33A mutant
Descriptor: Mu-theraphotoxin-Cg1a
Authors:Landon, C, Meudal, H.
Deposit date:2023-02-13
Release date:2023-07-26
Method:SOLUTION NMR
Cite:Structure-function relationship of new peptides activating human Na v 1.1.
Biomed Pharmacother, 165, 2023
8CJS
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BU of 8cjs by Molmil
JzTx-34 toxin peptide W31A mutant
Descriptor: Mu-theraphotoxin-Cg1a
Authors:Landon, C, Meudal, H.
Deposit date:2023-02-13
Release date:2023-07-26
Method:SOLUTION NMR
Cite:Structure-function relationship of new peptides activating human Na v 1.1.
Biomed Pharmacother, 165, 2023
8CJR
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BU of 8cjr by Molmil
JzTx-34 toxin peptide W25A mutant
Descriptor: Mu-theraphotoxin-Cg1a
Authors:Landon, C, Meudal, H.
Deposit date:2023-02-13
Release date:2023-07-26
Method:SOLUTION NMR
Cite:Structure-function relationship of new peptides activating human Na v 1.1.
Biomed Pharmacother, 165, 2023
8CJQ
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BU of 8cjq by Molmil
JzTx-34 toxin peptide E20A mutant
Descriptor: Mu-theraphotoxin-Cg1a
Authors:Landon, C, Meudal, H.
Deposit date:2023-02-13
Release date:2023-07-26
Method:SOLUTION NMR
Cite:Structure-function relationship of new peptides activating human Na v 1.1.
Biomed Pharmacother, 165, 2023
8CJP
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BU of 8cjp by Molmil
JzTx-34 toxin peptide H18A mutant
Descriptor: Mu-theraphotoxin-Cg1a
Authors:Landon, C, Meudal, H.
Deposit date:2023-02-13
Release date:2023-07-26
Method:SOLUTION NMR
Cite:Structure-function relationship of new peptides activating human Na v 1.1.
Biomed Pharmacother, 165, 2023
8CIQ
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BU of 8ciq by Molmil
JzTx-34 toxin peptide
Descriptor: Mu-theraphotoxin-Cg1a
Authors:Landon, C, Meudal, H.
Deposit date:2023-02-10
Release date:2023-07-26
Method:SOLUTION NMR
Cite:Structure-function relationship of new peptides activating human Na v 1.1.
Biomed Pharmacother, 165, 2023
7K48
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BU of 7k48 by Molmil
Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV
Descriptor: Maltose/maltodextrin-binding periplasmic protein,Ion transport protein,Sodium channel protein type 9 subunit alpha chimera, Mu-theraphotoxin-Hs2a
Authors:Wisedchaisri, G, Tonggu, L, Gamal El-Din, T.M, McCord, E, Zheng, N, Catterall, W.A.
Deposit date:2020-09-15
Release date:2020-12-02
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural Basis for High-Affinity Trapping of the Na V 1.7 Channel in Its Resting State by Tarantula Toxin.
Mol.Cell, 81, 2021
6W6O
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BU of 6w6o by Molmil
NaChBac-Nav1.7VSDII chimera and HWTX-IV complex
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Huwentoxin-IV, NaChBac-Nav1.7VSDII chimera
Authors:Yan, N, Gao, S.
Deposit date:2020-03-17
Release date:2020-06-24
Last modified:2021-01-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na + channels in nanodisc.
Proc.Natl.Acad.Sci.USA, 117, 2020
6V6T
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BU of 6v6t by Molmil
Solution structure of delta-theraphotoxin-Hm1b from Heteroscodra maculata
Descriptor: Delta-theraphotoxin-Hm1b
Authors:Chin, Y.K.Y, Chow, C.Y, King, G.F.
Deposit date:2019-12-05
Release date:2020-05-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A selective Na V 1.1 activator with potential for treatment of Dravet syndrome epilepsy.
Biochem Pharmacol, 181, 2020
6MK5
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BU of 6mk5 by Molmil
Solution NMR structure of spider toxin analogue [F5A,M6F,T26L,K28R]GpTx-1
Descriptor: Toxin GTx1-15
Authors:Schroeder, C.I.
Deposit date:2018-09-25
Release date:2018-12-19
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1.
ACS Chem. Biol., 14, 2019
6GFT
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BU of 6gft by Molmil
Antinociceptive evaluation of cyriotoxin-1a, the first toxin purified from Cyriopagopus schioedtei spider venom
Descriptor: cyriotoxin-1a
Authors:Kurz, M.
Deposit date:2018-05-02
Release date:2019-03-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei.
Br.J.Pharmacol., 176, 2019
6BTV
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BU of 6btv by Molmil
Solution NMR structures for CcoTx-II
Descriptor: Beta-theraphotoxin-Cm1b
Authors:Agwa, A.J, Schroeder, C.I.
Deposit date:2017-12-07
Release date:2018-05-09
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes.
J. Biol. Chem., 293, 2018
6BR0
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BU of 6br0 by Molmil
Solution NMR structure for CcoTx-I
Descriptor: Beta-theraphotoxin-Cm1a
Authors:Agwa, A.J, Schroeder, C.I.
Deposit date:2017-11-29
Release date:2018-05-16
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes.
J. Biol. Chem., 293, 2018
6AV8
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BU of 6av8 by Molmil
Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox
Descriptor: U5-theraphotoxin-Hs1b 1
Authors:Gewe, M.M, Rupert, P, Strong, R.K.
Deposit date:2017-09-01
Release date:2018-02-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Screening, large-scale production and structure-based classification of cystine-dense peptides.
Nat. Struct. Mol. Biol., 25, 2018
5WLX
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BU of 5wlx by Molmil
Solution structure of kappa-theraphotoxin-Aa1a
Descriptor: Kappa-theraphotoxin-Aa1a
Authors:Chin, Y.K.Y, Ma, L, King, G.F.
Deposit date:2017-07-28
Release date:2018-08-01
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target.
Biochem. Pharmacol., 158, 2018
5WE3
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BU of 5we3 by Molmil
Solution NMR structure of PaurTx-3
Descriptor: Beta-theraphotoxin-Ps1a
Authors:Agwa, A.J, Schroeder, C.I.
Deposit date:2017-07-06
Release date:2017-09-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins.
Toxins (Basel), 9, 2017
5TLR
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BU of 5tlr by Molmil
Solution NMR structure of gHwTx-IV
Descriptor: Mu-theraphotoxin-Hs2a
Authors:Agwa, A.J, Schroeder, C.I.
Deposit date:2016-10-11
Release date:2017-02-22
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7.
Biochim. Biophys. Acta, 1859, 2017
5T3M
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BU of 5t3m by Molmil
Solution structure of a triple mutant of HwTx-IV - a potent blocker of Nav1.7
Descriptor: Mu-theraphotoxin-Hs2a
Authors:Rahnama, S, Sharma, G, Mobli, M.
Deposit date:2016-08-25
Release date:2017-09-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.
PLoS ONE, 12, 2017
5I2P
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BU of 5i2p by Molmil
Resonance assignments and NMR structure determination of tarantula toxin- W7A mutant of mu-TRTX-Pre1a (W6A in native sequence numbering)
Descriptor: W7A mu-TRTX-Pre1a Toxin
Authors:Chin, Y.K.-Y, Wingerd, J.S, Mobli, M, Rash, L.D.
Deposit date:2016-02-09
Release date:2017-06-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Resonance assignments and NMR structure determination of tarantula toxin- W7A mutant of mu-TRTX-Pre1a
To Be Published
5I1X
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BU of 5i1x by Molmil
Resonance assignments and NMR structure determination of tarantula toxin, F8A mutant of beta-TRTX-Pre1a
Descriptor: mu-TRTX-Pre1a toxin
Authors:Chin, Y.K.-Y, Wingerd, J.S, Mobli, M, Rash, L.D.
Deposit date:2016-02-07
Release date:2017-02-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Resonance assignments and NMR structure determination of tarantula toxin, mu-TRTX-Pre1a
To Be Published
5EPM
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BU of 5epm by Molmil
Ceratotoxin variant in complex with specific antibody Fab fragment
Descriptor: Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, Beta-theraphotoxin-Cm1a
Authors:Strop, P, Shcherbatko, A, Rossi, A.
Deposit date:2015-11-11
Release date:2016-05-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain.
J.Biol.Chem., 291, 2016
3J5Q
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BU of 3j5q by Molmil
Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy
Descriptor: Kappa-theraphotoxin-Cg1a 1, Transient receptor potential cation channel subfamily V member 1
Authors:Liao, M, Cao, E, Julius, D, Cheng, Y.
Deposit date:2013-10-28
Release date:2013-12-04
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:TRPV1 structures in distinct conformations reveal activation mechanisms.
Nature, 504, 2013
2WH9
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BU of 2wh9 by Molmil
Solution structure of GxTX-1E
Descriptor: GUANGXITOXIN-1EGXTX-1E
Authors:Lee, S.K, Jung, H.H, Lee, J.Y, Lee, C.W, Kim, J.I.
Deposit date:2009-05-02
Release date:2010-05-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution Structure of Gxtx-1E, a High Affinity Tarantula Toxin Interacting with Voltage Sensors in Kv2.1 Potassium Channels.
Biochemistry, 49, 2010

 

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